Molecular Genetics & Genomics 2020-2021
Genetics is the study of the information system underlying biological systems and how it is transmitted across generations. Genomics is the analysis and manipulation of whole genomes of genetic information. Discoveries in these areas help elucidate the basis for living systems, and can identify the causes and potential cures for human disease.
Through this concentration, students will gain a detailed understanding of how cells encode, express, and pass on genetic information. The classes for this concentration use primary research sources to cover such cutting-edge topics as epigenetics (chromatin modification and its consequences), non-coding RNA (RNAi and micro RNAs), and application of molecular biology in biomedical research.
REQUIREMENTS AS PER 2020-2021 CATALOG
Any three of the following courses:
- BIOL_SCI 332-0 Conservation Genetics - Understanding the effects of climate change, habitat fragmentation, invasive species, pollution and other environmental factors impact the genetics of populations and how to conserve, manage, and restore genetic diversity. Prerequisites: BIOL SCI 215, BIOL SCI ENVR SCI 202, or BIOL SCI 341.
- BIOL_SCI 354-0 Quantitative Analysis in Biology - Each module (of which there will be five or six) will end with analysis of a data set acquired from the authors of the studies, with re-analysis and re-plotting of a central result therefrom. En route to this, the course covers the mathematics, physics, and statistics required to produce the plots. The landmark papers include studies in gene regulation, developmental biology, gene sequencing, etc. There will also be aspects of coding, image analysis, random genetic processes, gene expression, cell adaptation, the cell cycle, developmental morphogens, and phylogenomics. Prerequisites: BIOL SCI 215 and 219, and PHYSICS 130-2 or 135-2; or, permission of instructor.
- BIOL_SCI 359-0 Quantitative Experimentation in Biology - This course is taught as four modules, in which students replicate experiments from some of the landmark papers in the history of quantitative biology. Groups of students will work together and learn how to perform experiments in a wet lab setting, perform live imaging, conduct sequencing-based studies, analyze their own data, and present results in a professional manner. Prerequisites: BIOL SCI 354, or permission of instructor.
- BIOL_SCI 378-0 Functional Genomics - Patterns of gene expression and their causes. Prerequisites: BIOL_SCI 215-0, BIOL_SCI 219-0; a course in statistics.
- BIOL_SCI 390-0 Advanced Molecular Biology - Emphasizes coverage of molecular genetic mechanisms in eukaryotic organisms. Topics include basic concepts and techniques of molecular biology, the organization of genetic information, the flow of genetic information, regulation of the flow of genetic information, and various applications of molecular biology in biomedical research. Prerequisites: BIOL SCI 215, 219, and either 301 or 308.
- BIOL_SCI 391-0 Development & Evolution of Body Plans - Molecular mechanisms underlying early embryonic development, including establishment of the body and organogenesis. Discussion of original literature. Prerequisites: BIOL_SCI 215-0, BIOL_SCI 219-0; BIOL_SCI 301-0 or BIOL_SCI 308-0.
- BIOL_SCI 393-0 Biomedical Genetics - Will dive deeply into the logic and methods of transmission and regulatory genetics, including complementation, recombination, genetic modifiers, chromosomal aberrations, genetic screens, and the “genetic toolbox” in diverse species, including humans. Other topics will include genome-wide association studies, linkage analysis, and the roles of both rare and common genetic variation in human disease. There will be lectures provided, but emphasis will be placed on problem-solving and active discussion. Prerequisites: BIOL SCI 215, 219, and either 301 or 308.
- BIOL_SCI 395-0 Molecular Genetics - Exploration of recent advances that have revolutionized the fields of gene expression and cell regulation. Discussion of articles and primary research papers. Prerequisite: BIOL_SCI 378-0, BIOL_SCI 390-0, or BIOL_SCI 393-0.
- BIOL_SCI 396-0 Mushroom Genetics & Genomics - Utilizing a mushroom-forming fungus, Schizophyllum coummune, students in this laboratory-based course will undertake scientific investigations designed to discover new knowledge. Under the guidance of the instructor, each student will be provided with specimens from a nation-wide collection of wild S. commune specimens, with which they will carry out molecular, genetic, and genomic experiments and analyses. Students will also analyze Schizophyllum specimens that she/he has collected in the local environment. Experiments will include generating new mutations, determining the molecular sequences of the genes that control mushroom mating, and performing molecular “barcoding” to establish phylogenetic relationships among members of the Schizophyllum population. Prerequisites: BIOL SCI 215 and 222.
2020-2021 Course Offerings for this Concentration
|BIOL_SCI 332-0||Conservation Genetics||Staff|
|BIOL_SCI 354-0||Quantitative Analysis of Biology||Madhav Mani|
|BIOL_SCI 378-0||Functional Genomics||Eric Weiss|
|BIOL_SCI 390-0||Advanced Molecular Biology||Xioazhong Alec Wang|
|BIOL_SCI 393-0||Human Genomics||Erik Andersen|
|BIOL_SCI 395-0||Molecular Genetics||Richard Gaber|
|BIOL_SCI 396-0||Evolution and Diversity: Mushroom Genetics & Genomics||Richard Gaber|